AMC 120, Glofitamab Plus Chemoimmunotherapy in Newly Diagnosed HIV-Associated Large B-Cell Lymphoma (The "Glofit-RCHOP Study")

NCT07649304 · clinicaltrials.gov ↗

PHASE1

Phase

NOT_YET_RECRUITING

Status

15

Enrollment

NIH

Sponsor class

Conditions

AIDS-Related Diffuse Large B-cell Lymphoma
Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
High Grade B-Cell Lymphoma With MYC and BCL2 Rearrangements
High Grade B-Cell Lymphoma, Not Otherwise Specified
Lugano Classification Stage II Adult Non-Hodgkin Lymphoma AJCC v8
Lugano Classification Stage III Adult Non-Hodgkin Lymphoma AJCC v8
Lugano Classification Stage IV Adult Non-Hodgkin Lymphoma AJCC v8
Plasmablastic Lymphoma
Primary Effusion Lymphoma

Interventions

PROCEDURE: Biopsy Procedure
PROCEDURE: Biospecimen Collection
PROCEDURE: Bone Marrow Aspiration
PROCEDURE: Bone Marrow Biopsy
PROCEDURE: Computed Tomography
DRUG: Cyclophosphamide
DRUG: Doxorubicin Hydrochloride
PROCEDURE: Echocardiography Test
BIOLOGICAL: Glofitamab
PROCEDURE: Positron Emission Tomography
DRUG: Prednisone
OTHER: Questionnaire Administration
BIOLOGICAL: Rituximab
DRUG: Vincristine Sulfate

Sponsor

National Cancer Institute (NCI)