THE SYNTHESIS OF RAVIDOMYCIN AND OF ANALOGUES

NIH RePORTER · NIH · R01 · $70,430 · view on reporter.nih.gov ↗

Abstract

The total synthesis of the antitumor drug ravidomycin is proposed. The naphthalene aglycone of this C-glycoside is also found in toromycin and gilvogarcin V. The plan is to append the deoxyaminoaltrose sugar onto a properly functionalized benzoquinone. The synthetic methodology which is envisioned for the connection of ring D is a Meerwein arylation or a palladium mediated arylation of benzoquinone.

Key facts

NIH application ID
3174459
Project number
5R01CA036868-03
Recipient
UNIVERSITY OF ALABAMA IN TUSCALOOSA
SAM.gov UEI
RCNJEHZ83EV6
Principal Investigator
THOMAS C MC KENZIE
Activity code
R01
Funding institute
NIH
Fiscal year
1987
Award amount
$70,430
Award type
5
Project period
1985-05-01 → 1988-04-30